| 附子相杀、相畏配伍减毒实验研究 |
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| 引用本文： | 张广平,解素花,朱晓光,张思玉,叶祖光.附子相杀、相畏配伍减毒实验研究[J].中国中药杂志,2012,37(15):2215-2218. |
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| 作者姓名： | 张广平 解素花 朱晓光 张思玉 叶祖光 |
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| 作者单位： | 1. 中药复方新药开发国家工程研究中心,北京,100075
2. 中国中医科学院,北京,100700 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)项目(2009CB522806) |
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| 摘 要： | 目的:根据古代本草关于附子相杀、相畏的记载,研究与附子具有相杀、相畏配伍的中药对附子毒性的影响。方法:ICR小鼠,40μL.g-1体重灌胃给药,平行比较了附子分别配伍不同比例防风、黄芪、远志前后的急性毒性,测定其半数致死剂量(LD50);SD大鼠,十二指肠注射给药,20μL.g-1体重,平行比较了附子分别配伍不同比例防风、黄芪、远志前后的心脏毒性,测定其半数中毒剂量(TD50)。结果:附子配伍各药后可不同程度的提高附子的LD50和心脏毒性的TD50,减毒作用与药物的配伍比例有关。结论:相杀、相畏配伍是我国古代先贤在应用有毒中药过程中实践的总结,具有一定的科学性。
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| 关 键 词： | 配伍减毒 附子 相杀 相畏 |
| 收稿时间： | 2012/4/26 0:00:00 |
Experimental study on combination attenuation of mutual-detoxication and mutual restraint about Aconiti Carmichaeli Radix |
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| ZHANG Guangping,XIE Suhu,ZHU Xiaoguang,ZHANG Siyu and YE Zuguang.Experimental study on combination attenuation of mutual-detoxication and mutual restraint about Aconiti Carmichaeli Radix[J].China Journal of Chinese Materia Medica,2012,37(15):2215-2218. |
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| Authors: | ZHANG Guangping XIE Suhu ZHU Xiaoguang ZHANG Siyu and YE Zuguang |
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| Institution: | National Engineering Research Center for Traditional Chinese Medicine Compound Drug Development, Beijing 100075, China;National Engineering Research Center for Traditional Chinese Medicine Compound Drug Development, Beijing 100075, China;National Engineering Research Center for Traditional Chinese Medicine Compound Drug Development, Beijing 100075, China;National Engineering Research Center for Traditional Chinese Medicine Compound Drug Development, Beijing 100075, China;China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Objective: According to the record of mutual-detoxication and mutual restraint in ancient Chinese materia medica,to research the influence to the toxicity of Aconiti Carmichaeli Radix added the traditional Chinese medicine(TCM) which is mutual-detoxication and mutual restraint to it.Method: ICR mouse,0.4 μL·g-1,to pour the fluid into stomach,paired comparison of acute toxicity of Aconiti Carmichaeli Radix seperately added different ratio of Sileris Radix,Astragali Radix and Polygalae Radix,and admeasure the dose for LD50.SD rats,administration by injection through duodenum,20 μL·g-1,paired comparison of heart toxicity of Aconiti Carmichaeli Radix seperately added different ratio of Sileris Radix,Astragali Radix and Polygalae Radix,and admeasure the dose for TD50.Result: LD50 and heart toxicity of TD50 were increased after Aconiti Carmichaeli Radix added separately,its toxicity attenuation is related to the ratio.Conclusion: Mutual-detoxication and mutual restraint are the summary drawed when China ancient people is in the process of using toxic TCM and it is scientific. |
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| Keywords: | compatibility for attenuation Aconiti Carmichaeli Radix mutual detoxication mutual restraint |
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