Advanced glycation end products in children with chronic renal failure and type 1 diabetes |
| |
Authors: | Misselwitz Joachim Franke Sybille Kauf Eberhard John Ulrike Stein Günter |
| |
Institution: | (1) Department of Pediatrics and Department of Internal Medicine IV, Friedrich-Schiller University, Jena, Germany, DE;(2) Klinikum der FSU, Klinik für Kinder- und Jugendmedizin, Kochstrasse 2, 07745 Jena, Germany e-mail: joachim.misselwitz@med.uni-jena.de Tel.: +49-36-41938213, Fax: +49-3641-938366, DE |
| |
Abstract: | Serum levels of advanced glycation end products (AGEs) are markedly elevated in adults with chronic renal failure (CRF) and
diabetes mellitus. Accumulation of AGEs in tissues contributes to the development of long-term complications. Up to now little
has been known about the formation of AGEs in childhood. We determined serum levels of the well known AGEs pentosidine and
Nɛ-carboxymethyllysine (CML) in children with CRF (n=12), end-stage renal disease (ESRD) (n=9), renal transplantation (n=12), and type 1 diabetes mellitus (n=42) and in healthy children (n=20). Pentosidine was measured by high-performance liquid chromatography (HPLC), CML by a competitive enzyme-linked immunosorbent
assay (ELISA) system. Serum levels of pentosidine and CML were significantly higher in the children with CRF and ESRD than
in controls (P<0.001), but nearly within the normal range after transplantation. Both AGEs showed a significant negative correlation with
creatinine clearance (P<0.001). During a single session of low-flux hemodialysis, total pentosidine and CML levels did not change. Free pentosidine,
however, was reduced by 78% (P=0.04). Diabe-tic children showed significantly elevated pentosidine levels (P<0.001) despite normal renal function. We conclude that, similar to adults, increased formation and accumulation of AGEs also
exist in children with CRF and type 1 diabetes mellitus. At present the best prevention of AGE-related complications is an
early renal transplantation in children with ESRD, as well as a careful metabolic monitoring of diabetics.
Received: 25 July 2001 / Revised: 14 November 2001 / Accepted: 18 November 2001 |
| |
Keywords: | Advanced glycation end products Pentosidine Carboxymethyllysine Chronic renal failure Type 1 diabetes Children |
本文献已被 PubMed SpringerLink 等数据库收录! |
|