新三联方案根除幽门螺杆菌的疗效观察

目的观察含左氧氟沙星新三联方案对标准三联疗法根除幽门螺杆菌（Helicobacter pylori，Hp）失败患者进行补救治疗的根除效果。方法将标准三联疗法根除Hp失败的50例患者随机分为2组：治疗组给予奥美拉唑20mg＋左氧氟沙星200mg＋阿莫西林1000mg，口服7d，均2次／d；对照组给予胶体次枸橼酸铋钾200mg＋奥美拉唑20mg＋克拉霉素500mg＋阿莫西林1000mg，口服7d，均2次／d；治疗后4周行快速尿素酶试验和14C-尿素呼气试验，观察其根除率。结果50例患者中有45例完成治疗，治疗组按意图治疗（ITT）分析幽门螺杆菌根除率为76．00％（19／25），按试验方案（PP）为82．61％（19／23），对照组根除率按ITT为60．00％（15／25），按PP为68．18％（15／22），均显著低于治疗组（P〈0．05）。结论对Hp根除治疗失败的患者，新三联方案较四联疗法能获得较高的根除率，且副反应较小。

Effect of levofioxacin,amoxicillin and omeprazole triad system as rescue therapy for Helicobacter pylori infection

Objective To evaluate the effect of rescue therapy for eradicating Helicobaeter pylori （Hp） with levofloxaein amoxieillin and omeprazole triad system. Methods Fifty patients with Helieobaeter pylori infection were randomized divided treatment group and control group, 25 patients of treatment group treated with omeprazole 20 mg, levofloxaein 20 mg,amoxieillin 1 000 rag,and 25 patients of control group treated with eollodial bismuth subeitrate 200 mg, omeprazole 20 mg, amoxieillin 1 000 mg,elarithromyein 500 mg bid for 7 days. The 14C-urea breath test （UBT）was performed to evaluate the success of Hp eradication ,at least four weeks after completion of therapy. Results By intention-to-treat（ITT） analysis and per-protoeol（PP） analysis,the rates of eradication ofH. pylori of treatment group were 76.00G（19/25）and 82.61%（19/23） respectively. The ratesof eradication of control group were 60. 00G（15/25） and 68. 18%（15/22） respectively, which were lower significantly than that of treatment groups （P〈0.05）. Conclusion Levofloxaein, amoxieillin and omeprazole triad system as rescue therapy has a satisfactory eradicating rate for previous treatment failure of H. pylori infection.