PM_(2.5)与变应性鼻炎患者上气道阻力的相关性研究

目的探讨变应性鼻炎(AR)患者上气道阻力与其周边环境PM_(2.5)浓度的关系。方法随机选取60例在临床上确诊为AR的患者行鼻声反射和鼻阻力测量,并连续监测其生活地区的PM_(2.5)浓度,使用SPSS 20.0统计软件,采用多元线性回归模型,对所纳入患者的鼻腔总阻力、鼻腔容积和鼻腔最小横截面积与空气污染暴露水平的关联进行分析。结果鼻声反射和鼻阻力测量结果显示,受试者鼻腔总阻力、鼻腔最小横截面积、鼻腔容积随着PM_(2.5)浓度的变化动态改变,差异具有统计学意义。结论 PM_(2.5)的浓度变化影响AR患者的上气道阻力,PM_(2.5)的浓度越大、暴露时间越长,AR患者的上气道阻力越大。

Correlation between PM2.5 and upper airway resistance in patients with allergic rhinitis

Objective To investigate the relationship between upper airway resistance and the concentration of atmospheric particulate matter with diameter <2.5 micrometers(PM_2.5)in patients with allergic rhinitis(AR). Methods Sixty patients with clinically diagnosed AR were randomly selected for nasal acoustic reflex and nasal resistance measurement. The PM_2.5 concentration in their living areas was continuously monitored. Using SPSS 20.0 statistical software, multiple linear regression models were used. The patient's total nasal resistance, nasal volume, and nasal minimum cross-sectional area were correlated with the air pollution exposure levels. The level of significance was set at P<0.05. Results Nasal acoustic reflex and nasal resistance measurements showed that the total nasal resistance, nasal minimum cross-sectional area, and nasal volume of the subject varied dynamically with varying PM_2.5 concentration, and the difference was statistically significant. Conclusion The concentration of PM_2.5 affects the upper airway resistance of patients with AR. The greater the concentration of PM_2.5 and longer the exposure time, the greater the upper airway resistance of patients with AR.