鼻腔冲洗联合鼻用糖皮质激素对AR患者FeNO、肺功能及生活质量的影响

目的探讨变应性鼻炎(AR)患者采用鼻腔冲洗联合鼻用糖皮质激素治疗对呼出气一氧化氮(FeNO)、肺功能及生活质量的影响。方法选取我院2016年3月至2017年3月收治的AR患者120例,采用随机数字表法分为观察组和对照组各60例,对照组采用布地奈德喷雾剂治疗,60μg,每侧1次,每日早晚1次,连续治疗3个月;观察组早晚各采用100 mL生理盐水冲洗治疗,每侧早晚各冲洗1次,冲洗后采用布地奈德鼻喷雾剂治疗,连续治疗3个月。对比两组的FeNO、用力肺活量占预计值的百分比(FVC%)、第1秒用力肺活量占预计值的百分比(FEV1%)、最高呼气流速(PEF)、平静呼气肺活量(VC%)占预计值的百分比及鼻-结膜炎相关生活质量问卷(RQLQ)评分。结果治疗后观察组与对照组FeNO水平分别为(750.2±89.4)×10-10mol/L、(816.3±92.7)×10-10mol/L,两组FeNO水平比较差异有统计学意义(t=-3. 976,P <0. 001)。治疗后,观察组FVC%、FEV1%、PEF%、VC%水平高于对照组(t分别为3.207、4.211、2.780、3.272,P分别为0.002、<0.001、0.006、0.001)。治疗后观察组与对照组RQLQ评分分别为(29.0±6.4)、(34.4±7.0)分,两组比较差异有统计学意义(t=-4.410,P<0.001)。结论采用鼻腔冲洗联合鼻用糖皮质激素治疗AR能降低患者FeNO,在一定程度上改善患者肺功能,提高患者的生活质量。

Effect of nasal irrigation combined with intranasal corticosteroids to treat allergic rhinitis and influence on exhaled nitric oxide and lung function

Objective To investigate the effects of nasal irrigation combined with glucocorticoid on exhaled nitric oxide(FeNO), pulmonary function, and quality of life in patients with allergic rhinitis(AR). Methods A total of 120 AR patients, admitted to our hospital from March 2016 to March 2017, were selected and randomly divided into the observation group and control group(n=60 cases, each). The control group was treated with budesonide spray(60 μg, once on each side)once every morning and evening for 3 months. The observation group was treated with saline irrigation(100 mL, once on each side)once every morning and evening, and then with budesonide nasal spray for 3 months. The FeNO, FVC%, FEV₁%, PEF, VC%, and RQLQ scores were compared between the two groups. Results The levels of FeNO in the observation group and the control group were(750.2±89.4)×10^-10mol/L and(816.3±92.7)×10^-10mol/L, respectively, following treatment. There was a significant difference in the levels of FeNO between the two groups(t=-3.976, P<0.001). After treatment, the levels of FVC, FEV₁%, PEF, and VC% in the observation group were higher than those in the control group(t=3.207, 4.211, 2.780, 3.272 and P=0.002, <0.001, 0.006, 0.001, respectively). The RQLQ scores of the observation group and the control group were(29.0±6.4)and(34.4±7.0), respectively, with a statistically significant difference(t=-4.410, P<0.001). Conclusion Nasal irrigation combined with nasal glucocorticoid therapy can reduce FeNO, and improve the pulmonary function and quality of life of AR patients to a certain extent.