清胰汤治疗重症胰腺炎疗效及对炎症因子的影响

目的:探究清胰汤治疗重症胰腺炎临床疗效及对炎症因子的影响。方法 :选取2014年1月至2017年6月诊断为急性重症胰腺炎的104例住院患者,按照随机数字表法分成治疗组和对照组各52例。所有患者均予常规治疗。治疗组在常规治疗的基础上,予清胰汤鼻饲。比较两组中医证候评分、急性生理与慢性健康评分(APACHEⅡ评分)、炎症指标和安全指标。结果:两组治疗1周后中医证候积分均较治疗前显著降低,差异有统计学意义(P0.05),且治疗组治疗后腹痛、口干口渴和恶心呕吐的中医证候评分显著低于对照组,差异有统计学意义(P0.05)。治疗后两组APACHEⅡ评分均较治疗前显著降低,且治疗组治疗后的APACHEⅡ评分显著低于对照组,差异均有统计学意义(P0.05)。治疗后两组血白细胞(WBC)和白细胞介素-6(IL-6)均较治疗前显著下降,治疗后的IL-2较治疗前显著升高,且治疗组治疗后WBC和IL-6显著低于对照组,治疗组治疗后的IL-2显著高于对照组,差异均有统计学意义(P0.05)。两组治疗后的不良反应比较差异无统计学意义(P 0.05)。结论:清胰汤能有效改善重症胰腺炎的中医证候评分,降低重症胰腺炎的炎症因子。

Effects of Qingyi Decoction for Severe Acute Pancreatitis and Its Influence on Inflammatory Factors'

Objective:To assess the effect of Qingyi decoction for severe acute pancreatitis and its influence on inflammatory factors. Methods:A total of 104 patients with severe acute pancreatitis in our hospital from January 2014 to June 2017 were randomly divided into treatment group and control group,52 patients in each group. The patients in control group were given conventional therapy,and the patients in treatment group was treated with conventional treatments and Qingyi decoction through nasogastric gavage. Traditional Chinese medicine(TCM) symptom score,acute physiology and chronic health evaluation(APACHE) Ⅱ score,inflammatory factors and safety indexes were compared between two groups. Results:After 1-week treatment,TCM symptom scores in both group were significantly decreased after treatment(P<0.05),and TCM symptom scores of abdominal pain,xerostomia and vomiting in the treatment group were significantly lower than those in the control group(P<0.05). APACHE Ⅱ scores in two group were also significantly decreased after1-week treatment(P<0.05),and the APACHE Ⅱscore in treatment group were significantly lower than that in the control group(P<0.05). White blood cell(WBC) count and inter interleukin(IL)-6 level were also significantly decreased after 1-week treatment(P<0.05),and the WBC count and IL-6 level in treatment group were significantly lower than those in the control group(P<0.05). IL-2 level was increased after 1-week treatment(P<0.05),and IL-2 level in the treatment group were significantly high than that in the control group(P<0.05). But on the safety indexes there was no significant difference between both groups(P> 0.05). Conclusion:Qingyi decoction can reduce the clinical symptom and decrease the inflammatory factors in the patients with severe acute pancreatitis.