溃疡性结肠炎焦虑抑郁及其与主要症状、肠镜表现相关性研究

目的:观察溃疡性结肠炎(UC)患者焦虑、抑郁及其与主要症状、肠镜表现的相关性,为临床心理干预治疗UC提供依据。方法:将符合纳入标准的75例UC患者作为溃疡性结肠炎组(UC组),同时选取健康人群作为正常组。UC组观察焦虑自评症状量表(SAS)、抑郁自评症状量表(SDS)、主要症状、Baron肠镜评分、炎症性肠病生存质量问卷(IBDQ),同时观察正常组SAS、SDS。结果:UC组焦虑、抑郁评分高于正常组(P<0.05),焦虑发生率为20%,抑郁发生率为43%。UC组焦虑、抑郁评分与主要症状评分、IBDQ评分具有相关性(P<0.05),与Baron肠镜评分无相关性(P> 0.05)。结论:UC患者焦虑、抑郁发生率明显高于正常人,严重影响患者生活质量。UC患者焦虑、抑郁与主要症状关系密切,而与肠镜表现无明显相关性。在UC临床治疗中,要高度关注患者的焦虑、抑郁情况,尤其对临床症状表现较重的UC患者应及时进行心理评估,尽早进行心理干预,从而改善患者生活质量。

Anxiety and Depression in Patients with Ulcerative Colitis and Its Correlation to Cardinal Symptoms and Endoscopic Mucosal Manifestations

Objective:To observe anxiety and depression in patients with ulcerative colitis(UC) and its correlation to the cardinal symptoms and endoscopic mucosal manifestations,and provide the basis for clinical treatment of UC by psychological intervention. Methods:A total of 75 patients with UC in accordance with the inclusive criteria were selected as UC group,and the healthy people were selected as the control group.The self-rating anxiety scale(SAS),self-rating depression scale(SDS),cardinal symptoms,Baron endoscopic score and inflammatory bowel disease quality of life questionnaire(IBDQ) were observed in UC group,and the SAS and SDS were observed in the control group. Results:The SAS and SDS in UC group were higher than those of the control group(P< 0.05),and the incidence of anxiety and depression were 20%,43% respectively. The SAS and SDS were correlated to the cardinal symptoms and IBDQ in UC group(P< 0.05). However,the SAS and SDS were not correlated to Baron endoscopic score(P> 0.05). Conclusions:The incidence rate of anxiety and depression in patients with UC is significantly higher than healthy people,and seriously affect the quality of life. The anxiety and depression are closely associated with the main symptoms of UC,but have no significant correlation with endoscopic mucosal manifestations. In the treatment of UC,the patients who have severe clinical symptoms should receive a timely psychological assessment,and have a psychological intervention as soon as possible,so as to improve the quality of life.