诱导化疗在局部晚期下咽癌治疗中的意义

下咽癌发生位置隐蔽，早期症状不明显，超过2/3的下咽癌临床上初诊时为中晚期，是头颈肿瘤中预后较差的一种恶性肿瘤。近年来，倡导手术、放疗与化疗相结合的综合治疗模式以改善预后。诱导化疗在器官保留以及减少远处转移上的治疗价值日渐受到重视。但在实际临床工作中，主管医师对指南和各治疗手段利弊的理解以及临床经验的差异，诱导化疗在局部晚期下咽癌治疗中的作用仍存在争议。如何根据患者的全身和局部情况在众多的治疗方法中选择最合理的治疗手段是下咽癌治疗过程中一直在探讨的问题。通过文献回顾和个案剖析讨论诱导化疗在局部晚期下咽癌治疗中的作用。

Significance of induction chemotherapy in late treatment of locally advanced hypo-pharyngeal cancer

Early symptoms of hypopharyngeal cancer were not obvious because tumorigenesis in concealed areas. Almost 2/3 of hypopharyngeal cancer were diagnosed as middle and advanced stage, when first seeing a doctor.It is a malignant tumor with poor prognosis in head and neck tumors. In recent years, in order to improve the prognosis, we advocate a comprehensive treatment model combining surgery, radiotherapy and chemotherapy. Value of induction chemotherapy has been noticed in organ preservation and metastasis rate reduction. But in the actual clinical work, the role of induction chemotherapy (IC) in the treatment of locally advanced hypopharyngeal cancer has been disputed because every physicians′ understanding of the advantages and disadvantages of the guidelines and treatment methods and differences in clinical experience. How to choose the most reasonable one based on the patients′general and local conditions from many different treatment methods is an issue that has been explored in during treatment of hypopharyngeal cancer. This paper points out the author′s individual experience the induction chemotherapy in treatment of locally advanced hypopharyngeal cancer by literature review and case analyses.