电针对急性心肌缺血家兔心功能及心交感神经电活动的影响

目的:通过观察电针不同经穴对急性心肌缺血家兔心功能及心交感神经放电的影响,探讨原、络穴作用的相对特异性。方法:50只家兔随机分为正常对照组、模型对照组、电针神门组和电针支正组,采用静脉注射脑垂体后叶素复制急性心肌缺血模型。用Biopac生物信号采集系统记录神经电信号和心功能各指标;同时接入SKY-A4生物信号处理系统进行统计分析,记录电针"神门"支正"穴前后急性心肌缺血家兔心功能及心交感神经电活动的变化。结果:电针神门组、电针支正组在停针即刻心功能指标和心交感神经电活动与模型对照组比较均有统计学意义(P<0.05)。两组间比较,电针神门组各项指标改善优于电针支正组(P<0.05)。结论:电针"神门"支正"穴均可显著改善急性心肌缺血家兔的心功能并可提高心肌缺血状态下心交感神经的兴奋性,且电针"神门"穴的作用优于"支正"穴。

Effects of Electroacupuncture of "Shenmen" (HT 7) and "Zhizheng" (SI 7) on Cardiac Function and Electrical Activities of Cardiac Sympathetic Nerve in Acute Myocardial Ischemia Rabbits

Objective: To observe the effect of electroacupuncture(EA) of "Shenmen"(HT 7) and "Zhizheng"(SI 7) on cardiac function and electrical activities of the cardiac sympathetic nerve in acute myocardial ischemia rabbits.Methods: Forty livid-blue rabbits were randomly divided into normal control,model,"Shenmen"(HT 7) and "Zhizheng"(SI 7) groups with 10 cases in each group.Acute myocardial ischemia(AMI) model was established by intravenous injection of pituitrin(3 U/kg).Changes of heart rate(HR),maximum rising rate( dp/dt max) and maximum descending rate(-dp/dt max) of the left ventricular systolic pressure(LVSP),and discharges of cardiac sympathetic nerve(superior cardiac branch) were recorded.EA(2 Hz,5 V) was applied to bilateral "Shenmen"(HT 7) and "Zhizheng"(SI 7) for 30 min.Results: After AMI,HR,LVSP, dp/dt max and firing frequency of cardiac sympathetic nerve decreased significantly(P<0.01),and-dp/dt max increased obviously in model group(P<0.01).Compared with model group,HR, dp/dt max and cardiac sympathetic discharge of HT7 and SI7 groups increased significantly 10 min and 20 min after EA(P<0.05,0.01),and-dp/dt max of the later 2 groups reduced evidently 20 min after EA(P<0.05, 0.01).No significant differences were found between HT7 and control groups in HR,LVSP and the firing frequency of cardiac nerve 20 min and 30 min after EA,and between SI7 and control groups in the firing frequency of cardiac nerve 30 min after EA(P>0.05).The effects of group HT7 were significantly better than those of SI7(P<0.05).Conclusion: EA of both HT7 and SI7 can obviously improve cardiac function and electrical activity of cardiac sympathetic nerve in AMI,and the effects of HT7 are markedly better than those of SI7.