Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality |
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| Authors: | Wall Emma C Gordon Stephen B Hussain Samia Goonetilleke Upali R S Gritzfeld Jenna Scarborough Matthew Kadioglu Aras |
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| Affiliation: | Clinical Research Group, Liverpool School of Tropical Medicine, United Kingdom. |
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| Abstract: | Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option. |
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