Immunogenic effect of hepatitis B vaccine in children: comparison of two- and three-dose protocols |
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| Authors: | B Yvonnet P Coursaget E Petat E Tortey C Diouf F Barin F Denis I Diop-Mar J P Chiron |
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| Institution: | 1. Institut de Virologie de Tours, Facultés de Médecine et de Pharmacie, Tours, France;2. Faculté de Médecine et de Pharmacie, Dakar-Fann, Senegal, West Africa |
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| Abstract: | The immunogenic effect of hepatitis B vaccine was evaluated in 183 seronegative infants from Senegal. Seventy-two seronegative infants received two 5-micrograms doses of vaccine at a two-month interval and 111 seronegative infants received three 5-micrograms doses at one-month intervals. All the children had a booster dose one year after the first injection of vaccine. No difference between the two groups was observed in the seroconversion rate (93.1% and 94.6%, respectively); in the proportion of high anti-HBs titer; or in the anti-HBs geometric mean titer (82 and 92 mIU/ml, respectively). These results demonstrate that two doses of 5 micrograms of hepatitis B vaccine are sufficient in infants to obtain a high immunogenic effect. |
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| Keywords: | hepatitis B vaccine immunogenicitj |
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