| 丹红注射液对大鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 韩永鹏,安芸. 丹红注射液对大鼠脑缺血再灌注损伤的保护作用[J]. 药物评价研究, 2010, 0(5): 388-390 |
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| 作者姓名： | 韩永鹏 安芸 |
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| 作者单位： | [1]北京市中西医结合医院,北京100039 [2]菏泽医学专科学校,山东菏泽274030 |
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| 摘 要： | 目的：研究丹红注射液对大鼠缺血再灌注损伤的保护作用。方法：采用线栓法建立大鼠脑缺血再灌注模型,观察丹红注射液对脑缺血再灌注损伤大鼠的神经功能评分、脑组织中一氧化氮合酶（NOS）、一氧化氮（NO）、超氧化物歧化酶（SOD）、丙二醛（MDA）等的影响。结果：丹红注射液可显著降低脑缺血再灌注大鼠的神经功能评分,减轻脑组织损伤程度;提高SOD活力,降低MDA和NO、NOS水平。结论：丹红注射液对大鼠缺血再灌注损伤具有明显的保护作用。
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| 关 键 词： | 丹红注射液 脑缺血再灌注损伤 大鼠 神经功能 |
Protection of Danhong Injection on cerebral ischemia-reperfusion injury of rats |
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| HAN Yong-peng,AN Yun. Protection of Danhong Injection on cerebral ischemia-reperfusion injury of rats[J]. Drug Evaluation Research, 2010, 0(5): 388-390 |
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| Authors: | HAN Yong-peng AN Yun |
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| Affiliation: | 1 Beijing Hospital of Integrated Traditional and Western Medicine, Beijing 100039, China; 2 Heze Medical College, Heze 274030, China |
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| Abstract: | Objective：To investigate the protection of Danhong Injection on the cerebral ischemia-reperfusion injury of rats.Methods：The models of focal brain ischemia-reperfusion injury were prepared by middle cerebral artery occlusion （MCAO） in rats.The effects of Danhong Injection on the cerebral ischemia-reperfusion injury of rats, such as nerve function grade and contents of NOS, NO, SOD, and MDA in brain tissues, were observed.Results：Danhong Injection could decrease the nerve function grade, improve the vigor of SOD, depress the levels of MDA, NO, and NOS.Conclusion：Danhong Injection can protect the brain from ischemia-reperfusion injury in rats. |
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| Keywords: | Danhong Injection cerebral ischemia-reperfusion injury rat nerve function |
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