壳聚糖微/纳米粒在定向给药系统中的应用研究

目的：介绍壳聚糖微/纳米粒在新型定向给药系统中的应用,为发展安全高效的壳聚糖微/纳米粒定向给药系统提供参考。方法：综合近年来出版的有关文献,对壳聚糖基本性质,定位给药于各组织部位进行了探讨。结果：壳聚糖微/纳米粒可应用于脑、眼、鼻、口、肺、胃、小肠、结肠等器官靶向给药。结论：壳聚糖微/纳米粒作为一种新型药用辅料,在定位给药系统中已经得到了开发和应用。

Application of chitosan micro / nano particles in targeted drug delivery system

Objective： Chitosan micro / nano particles in novel targeted drug delivery system were reviewed to provide reference in development of safe and efficient chitosan micro / nano particles targeting drug delivery system. Methods： According to the literature published in the recent years, the basic nature of chitosan and it＇s targeted drug delivery in various tissues were discussed. Results： Chitosan micro / nano particles can be applied to brain, ophthalmic, nasal, buccal, pulmonary, stomach, small intestine, colon and other organs targeted drug delivery. Conclusion： Chitosan micro / nano particles, as a kind of novel pharmaceutical excipient, have been developed and applied in targeted drug delivery system.