脑心清片防治脑动脉硬化研究进展

脑心清片对脑动脉硬化具有良好的防治效果。近十多年国内外对脑心清片防治脑动脉硬化的临床、药理作用及其物质基础的广泛研究表明,脑心清片含有黄酮、有机酸和香豆素类等化学活性成分,脑心清片及其活性成分能降血压,降血脂,改善血液流变性,抑制血管内皮增生,抑制血小板聚集;调节免疫功能和抑制淋巴细胞与神经细胞的粘附,抑制炎症反应,改善神经细胞氧化还原状态,上调抗氧化基因表达,抗氧化清除自由基,抑制脂质过氧化,减轻缺血脑组织自由基损伤;此外,还能调节钙离子稳态,抗兴奋性谷氨酸毒性,抑制神经细胞凋亡和脑水肿,保护缺血脑组织抗脑缺血损伤;保护神经组织并促进神经细胞功能恢复等多方面、多层次、多靶点作用来阻断脑动脉硬化发生发展,从而发挥良好的防治脑动脉硬化症作用。

Advances in studies on prevention and treatment for cerebral arteriosclerosis of Naoxingqing Pellet

Naoxinqing （NXQ, only made from Leaves of Diospyros kaki by Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co. Ltd, Guangzhou） is a patented and approved drug of Traditional Chinese Medicine （TCM） used for the treatment of Cerebral Arteriosclerosis （CeA）. Much significant progress has been achieved in the extensive studies on the mechanism of NXQ effect of the prevention and treatment for Cerebral Arteriosclerosis. It is found that NXQ and its flavonoids components showed significant anti-Cerebral Arteriosclerosis and neuroproteetion against ischemia / reperfusion injury in vivo and in vitro. NXQ might lower serum level of lipid （TC, TG, LDL-C） and inhibit vascular endothelial proliferation, improve blood rheology, and inhibit platelet aggregation. NXQ could protect neuronal cells from injuries induced by hypoxia ＆ serum deprivation / recover, by oxidative stress, or by excito-toxic glutamate. Regulating immune function, inhibiting inflammation, improving the redox desequilibrium, up-regulating the anti-oxydative gene bcl-2 and activating the activity of L-type Ca^2＋ channel in Susceptible Neuron as well as inhibiting adhesion between lymphocytes and DRG might be responsible for the beneficial effects for Naoxinqing use in the treatment of Cerebral Arteriosclerosis. Flavonoids should be key and effective constituents of NXO.