| 四合木中的三萜类化学成分研究 |
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| 引用本文： | 丁琳琳,刘强,胡佳续,唐生安,段宏泉.四合木中的三萜类化学成分研究[J].药物评价研究,2010(3):216-219. |
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| 作者姓名： | 丁琳琳 刘强 胡佳续 唐生安 段宏泉 |
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| 作者单位： | [1]天津医科大学药学院基础医学研究中心,天津300070 [2]天津师范大学化学与生命科学学院,天津300387 |
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| 摘 要： | 目的：研究四合木Tetraena mongolica的化学成分。方法：采用硅胶柱色谱、凝胶柱色谱和HPLC制备色谱方法分离纯化得到单体化合物,采用有机波谱方法鉴定化合物结构。结果：从四合木醋酸乙酯提取物中分离得到5个化合物,分别为11α,12α：13β,28-diepoxyoleanane-3β-caffeate（1）,3β-hydroxy-11α,12α：13β,28-diepoxyoleanane（2）,3β-（3,4-dihydroxy-cinnamoyl）-erythrodiol（3）,槲皮素（4）,（E）-22-（3-（4-hydroxy-3-methoxyphenyl）acryloyloxy）docosanoic acid（5）。结论：化合物1～5均为首次从该属中分离得到,化合物1为未见报道的新化合物,化合物2为新天然产物。
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| 关 键 词： | 四合木 三萜 11α 12α：13β 28-diepoxyoleanane-3β-caffeate |
Chemical constituents of treterpenoids from Tetraena mongolica |
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| DING Lin-lin,LIU Qiang,HU Jia-xu,TANG Sheng-an,DUAN Hong-quan.Chemical constituents of treterpenoids from Tetraena mongolica[J].Drug Evaluation Research,2010(3):216-219. |
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| Authors: | DING Lin-lin LIU Qiang HU Jia-xu TANG Sheng-an DUAN Hong-quan |
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| Institution: | 1 School of Pharmaceutical Sciences,Research Center of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China;2 College of Chemistry and Life-Science,Tianjin Normal University,Tianjin 300387,China ) |
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| Abstract: | Objective：To study the chemical constituents from Tetraena mongolica.Methods：Chemical constituents were isolated and purified by repeated column chromatography（silica gel,Toyopearl HW-40C,and preparative HPLC）.Their structures were determined by 1H-NMR,13C-NMR,and 2D-NMR spectra methods.Results：Five compounds were isolated from the EtOAc extract of Tetraena mongolica and their structures were identified as follows：11α,12α：13β,28-diepoxyoleanane-3β-caffeate（1）,3β-hydroxy-11α,12α：13β,28-diepoxyoleanane（2）,3β-（3,4-dihydroxycinnamoyl）-erythrodiol（3）,quercetin（4）,（E）-22-3-（4-hydroxy-3-methoxyphenyl）acryloyloxy]docosanoic acid（5）.Conclusion：Compounds 1-5 are isolated from this plant for the first time,compound 1 is a new product,and compound 2 is a new natural product. |
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| Keywords: | Tetraena mongolica Maxim triterpene 11α 12α：13β 28-diepoxyoleanane-3β-caffeate |
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