重组人甲状旁腺素类似物PTH（1-34）在大鼠体内药动学研究

目的：研究大鼠scPTH（1-34）的药动学特征。方法：用125I标记PTH（1-34）示踪法对大鼠scPTH（1-34）后的血清药物浓度进行了测定,并用3P97程序拟和分析并计算药动学参数,采用超滤离心的方法进行药物与血浆蛋白结合率的研究。结果：大鼠scPTH（1-34）10、20和40μg/kg后,药物消除符合一房室模型。平均t1/2ke为（0.92±0.04）h;平均CL为（0.56±0.05）L/（kg.h）;Cmax和AUC0-8h均与剂量呈线性正相关,不同剂量药物与血浆蛋白平均结合率为13.4%。结论：大鼠scPTH（1-34）后,药物消除符合线性动力学特征。

In vivo pharmacokinetics of recombinant human parathyroid hormone analogue in rats

Objective：To study the pharmacokinetic characteristics on parathyroid hormone（PTH,1-34） after sc injection in rats.Methods：Serum drug concentration was measured by 125↑I labeled method after sc injection in rats,the pharmacokinetic model and parameters were fitted and calculated by the 3P97 program.Results：After sc injection at doses of 10,20,and 40 μg/kg in rats,the serum drug concentration-time curve was fitted to a one-compartment model.Mean t1/2ke was（0.92 ± 0.04） h and mean CL was（0.56 ± 0.05） L/（kg·h）.The Cmax and AUC0-8 h were positive linear correlation with the dose.Mean binding ratio of various doses drug with plasma protein was 13.4%.Conclusion：After sc injection of PTH（1-34） to rats,the elimination of PTH（1-34） could fit to the linear kinetics.