A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population. |
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| Authors: | H Thude S Rosenhahn W Hunger-Dathe U-A Müller D Barz |
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| Affiliation: | Institute for Transfusion Medicine, University of Jena, Jena, Germany. hansjoerg.thude@med.uni-jena.de |
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| Abstract: | To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not significantly different from the 1.2% found in the patient group (P = 0.922). The C to G transversion does not seem to be associated with susceptibility for T1D. |
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