| 微管解聚蛋白Ｓｔａｔｈｍｉｎ与肿瘤相关性的研究进展 |
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| 引用本文： | 孙洁,李志革.微管解聚蛋白Ｓｔａｔｈｍｉｎ与肿瘤相关性的研究进展[J].临床肿瘤学杂志,2010,15(7):658-661. |
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| 作者姓名： | 孙洁 李志革 |
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| 作者单位： | ５３００２１ 南宁 广西医科大学附属肿瘤医院化疗二科 |
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| 摘 要： | 微管解聚蛋白Ｓｔａｔｈｍｉｎ具有微管解聚活性，在细胞周期的转换过程中起着重要作用。在多种恶性肿瘤细胞中都可以检测到Ｓｔａｔｈｍｉｎ高表达。已有研究证实，Ｓｔａｔｈｍｉｎ蛋白的高表达能够影响某些作用于微管的化疗药物的疗效，抑制其表达可以提高这些药物的疗效。Ｓｔａｔｈｍｉｎ基因为肿瘤基因治疗提供了新的分子靶点。
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| 关 键 词： | Stathmin 细胞周期 微管 肿瘤治疗 |
| 收稿时间： | 2009-11-21 |
| 修稿时间： | 2010-01-28 |
Progression of microtubule-destabilizing protein stathmin in tumor |
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| SUN Jie,LI Zhi-ge.Progression of microtubule-destabilizing protein stathmin in tumor[J].Chinese Clinical Oncology,2010,15(7):658-661. |
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| Authors: | SUN Jie LI Zhi-ge |
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| Institution: | . (The Second Department of Chemotherapy, the Affiliated Tumor Hospital, Guangxi Medical University, Nanning 530021, China) |
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| Abstract: | Stathmin is a member of microtubule-destabilizing proteins. Stathmin has an effect on microtubules depolymerization, which play a critical role in the regulation of the cell cycle. The overexpression of stathmin was found in many kinds of human malignant tumors. Stathmin overexpresssion can affect the efficacy of antimicrotubule drugs. Stathmin expression inhibition can improve the efficacy of those antimicrotubule drugs in malignant cells. Stathmin gene provides an attractive molecular target for tumor therapy. |
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| Keywords: | Stathmin |
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