| 迟发性神经元损伤的实验研究——沙土鼠脑组织水和离子含量的变化 |
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| 引用本文： | 欧阳一冰,刘多三,杨同书.迟发性神经元损伤的实验研究——沙土鼠脑组织水和离子含量的变化[J].吉林大学学报(医学版),1991(2). |
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| 作者姓名： | 欧阳一冰 刘多三 杨同书 |
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| 作者单位： | 白求恩医科大学第一临床医学院神经内科
(欧阳一冰，刘多三)，白求恩医科大学地方病研究所生化研究室(杨同书) |
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| 摘 要： | 本文以结扎沙土鼠双侧项总动脉5min,然后使血流再通的方法制作迟发性神经元损伤动物模型。用原子吸收分光光度法测定了沙土鼠脑6个分区水和离子含量在脑缺血及缺血后重灌流1～96h的经时变化。实验结果表明,至重灌流24h,海马CA_1区组织钙浓度开始明显增高;随后在48h,水和钠含量亦增多;到96h,钾含量才出现显著性降低。除CA_1区外其它部位的脑组织中则没有上述变化。从本实验可以得出结论,即钙的过负荷加速了迟发性神经元损伤现象的产生。
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| 关 键 词： | 脑缺血 钙 海马 沙土鼠 |
EXPERIMENTAL STUDIES ON DELAYED NEURONAL DAMAGE (WATER AND ION LEVEL CHANGES IN GERBIL BRAIN) |
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| Ou-Yang Yibing,Liu Miao,Yang Tongshu,Liu Duosan.EXPERIMENTAL STUDIES ON DELAYED NEURONAL DAMAGE (WATER AND ION LEVEL CHANGES IN GERBIL BRAIN)[J].Journal of Jilin University: Med Ed,1991(2). |
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| Authors: | Ou-Yang Yibing Liu Miao Yang Tongshu Liu Duosan |
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| Institution: | Ou-Yang Yibing,Liu Miao,Yang Tongshu,Liu Duosan Department of Neurology,First Teaching Hospital |
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| Abstract: | Mongolian gerbil was used as the delayed neuronal damage (DND)animal model, and was submitted to 5-minute cerebral ischemia by bilateral carotid artery occlusion, followed by 1 to 96 hours reperfusion. Contents of water and ions were measured in 6 different brain regions at 7 time phases during ischemia and reperfusion. The results showed that in hippocampal CA1 sector, there was significant increase in calcium, water and sodium contents, and a decrease in potassium content at 24, 18 and 96 hours reperfusion time successively. Except CA1 sector, there were no similar changes in other regions. It is concluded that calcium overload accelerated the occurrence of DND. |
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| Keywords: | Cerebral ischemia Calcium Hippocampus Gerbil |
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