Cryptobiosis-inspired assembly of “AND” logic gate platform for potential tumor-specific drug delivery |
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| Authors: | Hu Zhou Gang He Yanbin Sun Jingguo Wang Haitao Wu Ping Jin Zhengbao Zha |
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| Institution: | aShenzhen Maternity and Child Healthcare Hospital, Shandong University, Shenzhen 518028, China;bSchool of Food and Biological Engineering, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, China |
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| Abstract: | Developing tumor-specific drug delivery systems with minimized off-target cargo leakage remains an enduring challenge. In this study, inspired from the natural cryptobiosis explored by certain organisms and stimuli-responsive polyphenol‒metal coordination chemistry, doxorubicin (DOX)-conjugated gelatin nanoparticles with protective shells formed by complex of tannic acid and FeIII (DG@TA-FeIII NPs) were successfully developed as an “AND” logic gate platform for tumor-targeted DOX delivery. Moreover, benefiting from the well-reported photothermal conversion ability of TA-FeIII complex, a synergistic tumor inhibition effect was confirmed by treating 4T1 tumor-bearing mice with DG@TA-FeIII NPs and localized near-infrared (NIR) laser irradiation. As a proof of concept study, this work present a simple strategy for developing “AND” logic gate platforms by coating enzyme-degradable drug conjugates with detachable polyphenol‒metal shells.KEY WORDS: Cryptobiosis, “AND” logic gate, Polyphenol‒metal chemistry, Drug delivery, Tumor microenvironment |
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