Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe? |
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Affiliation: | 1. Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China;2. Key Laboratory of Glycoconjugate Research, Ministry of Health, Shanghai 200032, China;3. Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai 200032, China;1. Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Canada;2. Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Canada;3. School of Life Science, Shanxi University, Taiyuan, China;4. School of Human Kinetics, Laurentian University, Sudbury, Canada;5. Department of Biology, Laurentian University, Sudbury, Canada;6. Health Science North Research Institute, Sudbury, Canada |
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Abstract: | In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-described effects, no OSC derivative is yet undergoing clinical trials even though their chemistry is well understood as OSCs act as hydrogen sulfide (H2S) donors. H2S is a biological mediator, synthesized through cysteine degradation and modulates vasodilation, cytoprotection, inflammation and angiogenesis. It is well accepted that H2S plays a biphasic pharmacological role: the inhibition of endogenous synthesis of H2S and paradoxically also the use of H2S donors to increase H2S concentration, induce both anti-cancer effects leading therefore to controversial discussions. Altogether, the role of H2S in the anti-cancer action of OSCs remains poorly understood. In this review, we hypothesize that OSCs act through H2S signaling pathways in cancer cells, and that a clearer understanding of the mechanism of action of H2S in OSC-mediated anti-cancer activity is required for further application of these compounds in translational medicine. |
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Keywords: | Cancer Organosulfur compounds Hydrogen sulfide Anti-cancer Biosynthesis |
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