Novel Chest Radiographic Biomarkers for COVID-19 Using Radiomic Features Associated with Diagnostics and Outcomes |
| |
Authors: | Jos Raniery Ferreira Junior Diego Armando Cardona Cardenas Ramon Alfredo Moreno Marina de Ftima de S Rebelo Jos Eduardo Krieger Marco Antonio Gutierrez |
| |
Institution: | Heart Institute, Clinics Hospital, University of Sao Paulo Medical School, Av. Dr. Enéas Carvalho de Aguiar 44, 05403000 São Paulo, Brazil |
| |
Abstract: | COVID-19 is a highly contagious disease that can cause severe pneumonia. Patients with pneumonia undergo chest X-rays (XR) to assess infiltrates that identify the infection. However, the radiographic characteristics of COVID-19 are similar to the other acute respiratory syndromes, hindering the imaging diagnosis. In this work, we proposed identifying quantitative/radiomic biomarkers for COVID-19 to support XR assessment of acute respiratory diseases. This retrospective study used different cohorts of 227 patients diagnosed with pneumonia; 49 of them had COVID-19. Automatically segmented images were characterized by 558 quantitative features, including gray-level histogram and matrices of co-occurrence, run-length, size zone, dependence, and neighboring gray-tone difference. Higher-order features were also calculated after applying square and wavelet transforms. Mann–Whitney U test assessed the diagnostic performance of the features, and the log-rank test assessed the prognostic value to predict Kaplan–Meier curves of overall and deterioration-free survival. Statistical analysis identified 51 independently validated radiomic features associated with COVID-19. Most of them were wavelet-transformed features; the highest performance was the small dependence matrix feature of “low gray-level emphasis” (area under the curve of 0.87, sensitivity of 0.85, ). Six features presented short-term prognostic value to predict overall and deterioration-free survival. The features of histogram “mean absolute deviation” and size zone matrix “non-uniformity” yielded the highest differences on Kaplan–Meier curves with a hazard ratio of 3.20 (). The radiomic markers showed potential as quantitative measures correlated with the etiologic agent of acute infectious diseases and to stratify short-term risk of COVID-19 patients. |
| |
Keywords: | COVID-19 Radiomics Coronavirus Chest radiography Medical image analysis |
|
|