生长激素在高龄病人腹部手术后的应用

目的:探讨高龄病人腹部手术后生长激素的应用. 方法:将近2年我院收治26例腹部手术的高龄病人随机分为治疗组及对照组,于手术后第2天开始,每天皮下分别注射重组人生长激素8 U或等渗盐水2 ml,连续7天,并应用肠外营养.术前及术后第3、8天测体重、血清清蛋白、右手握力、睡眠时间及拆线天数. 结果:术后血清清蛋白水平提高、体重增加、右手握力及睡眠时间的恢复,实验组均明显优于对照组(P<0.01).拆线时间实验组也短于对照组. 结论:生长激素能使高龄病人蛋白质合成增加,促进切口愈合,并可减轻术后疲劳综合征.

Effect of recombinant growth hormone on the aged patients after abdominal surgery

Objectives: To research the effects of recombinant human growth hormone(rhGH) with total parenteral nutrition(TPN) on the old patients following abdominal surgery. Methods: 26 old patients receiving TPN after major abdominal surgery were selected and distributed to study group(rhGH TPN, n =13) and control group(TPN only, n =13).For 7 days after operation, rhGH (8 U/d) or normal saline(in control group) were used. The patients' weight, serum albumin, right hand grip, sleep time and the time of incision cicatrized were determined. Results: The increase of weight, level of plasma albumin, grip power of right hand and sleep time were improved more in study group than those in control group. The incision cicatrized time was also shortened in study group. Conclusions: Growth hormone can promote protein synthesis, accelerate incision healing and reduce the postoperative fatigue syndrome.