PTEN、p53在子宫内膜浆液性癌和宫内膜样癌中的表达及临床病理意义

目的研究PTEN和p53在子宫内膜浆液性癌和宫内膜癌中的表达及临床病理意义。方法应用免疫组化方法检测26例宫内膜浆液性癌、42例宫内膜样癌和25例正常增生期宫内膜组织中PTEN、p53蛋白的表达。结果PTEN和p53蛋白在子宫浆液性癌、宫内膜样癌、正常增生期内膜中的阳性表达率分别为86.4%、28.6%、100%和76.9%、27.3%、0%。PTEN在子宫内膜样癌中阳性表达率明显低于浆液性癌(P<0.001)。p53蛋白表达与子宫内膜癌组织学类型、临床分期、病理分级、肌层浸润等因素有关(P<0.05)。结论PTEN突变和表达缺失与宫内膜样癌的发生、发展有关。p53基因突变和过表达与宫内膜浆液性癌发生发展关系密切。PTEN及p53蛋白检测对鉴别子宫浆液性癌与宫内膜样癌有重要价值。

Expression and significance of PTEN and p53 in uterine serous carcinoma and endometrioid carcinoma

Objective To investigaste the expression of PTEN and p53 and its clinicopathological significance in uterine serous carcinomas (USC) and endometrioid carcinomas(UEC). Methods The expression of PTEN and p53protein was detected with S-P immunohistochemitry in 26 cases of USC, 42 cases of UEC, and 20 cases of norma endometrium. Results were compared with the clinicopathological factors,such as histological type,clinical stage,pathological grade,myometrial invasion and lymph invasion. Results The positive expressing rates of PTEN and p53 in USC, UEC and normal endometrium were 84.6%, 28.6%, 100% and 76.9%, 27.3%, 0%, respectively. The positive expressing rate of PTEN in UEC was much more lower than that in USC(p=0.000). The positive expression of p53 correlated with histological types, clinical stages, pathological grades and myometrial invasion of endometrial carcinoma. Conclusion The loss of PTEN expression is closely related to tumorigenesis and development of the UEC, and the overexpression of p53 gene is related to tumorigenesis and development of the USC. The detection of PTEN and p53 protein may be useful in distinguishing the UEC from USC.