| MMP-2/TIMP-2在胎膜早破中的表达及意义 |
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| 引用本文： | 何银芳,张莉,杨海澜,郝敏,武桂花. MMP-2/TIMP-2在胎膜早破中的表达及意义[J]. 中国妇幼保健, 2009, 24(27): 3859-3861 |
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| 作者姓名： | 何银芳 张莉 杨海澜 郝敏 武桂花 |
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| 作者单位： | 山西医科大学第一附属医院产科,山西,太原,030001 |
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| 摘 要： | 目的:探讨基质金属蛋白酶-2(MMP-2)及其抑制因子-2(TIMP-2)的表达与胎膜早破发病的关系。方法:通过免疫组织化学方法检测胎膜早破组和正常对照组胎膜中MMP-2及TIMP-2的表达情况。结果:基质金属蛋白酶-2在胎膜早破组胎膜中的表达水平为(137.1333±17.83010),在正常对照组胎膜中的表达水平为(179.3667±16.07200),差异有统计学意义(P<0.01);基质金属蛋白酶抑制因子2在胎膜早破组胎膜中的表达水平为(166.7667±16.86597),在正常对照组胎膜中的表达水平为(173.9000±13.73229),差异无统计学意义(P>0.05)。结论:胎膜中基质金属蛋白酶-2蛋白的高表达可能是胎膜早破的病因之一。
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| 关 键 词： | 基质金属蛋白酶 基质金属蛋白酶抑制因子 胎膜早破 免疫组织化学 |
The expression and significance of MMP-2/TIMP-2 in cases with premature rupture of membrane |
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| Abstract: | Objective:To explore the expression levels of matrix metalloproteinase 2(MMP-2)and its inhibitor-tissue inhibitor of metalloproteinase-2(TIMP-2)and the relationship between MMP-2,TIMP-2 and premature rupture of membrane(PROM).Methods:The expression levels of MMP-2 and TIMP-2 in fetal membranes of PROM group and control group were detected by immunohistochemical method.Results:There was significant difference in the level of MMP-2 between PROM group(137.133 3±17.830 10)and control group(179.366 7±16.072 00)(P<0.01);but There was no significant difference in the level of TIMP-2 between PROM group(166.766 7±16.865 97)and control group(173.900 0±13.732 29)(P>0.05).Conclusion:The high level of MMP-2 in fetal membranes may be one of the causes of PROM. |
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| Keywords: | Matrix metalloproteinase Tissue inhibitor of matrix metalloproteinase Premature rupture of fetal membrane Immunohistochemistry |
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