脑利钠肽对子痫前期的早期预测价值 |
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引用本文: | 任秀聪,任立新,吕英璞,冯英丽.脑利钠肽对子痫前期的早期预测价值[J].中国妇幼保健,2009,24(35):4974-4975. |
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作者姓名: | 任秀聪 任立新 吕英璞 冯英丽 |
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作者单位: | 河北省石家庄市第一医院妇产科,050011 |
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摘 要: | 目的:探讨血清脑利钠肽(BNP)水平对子痫前期的早期预测价值。方法:采用荧光免疫法检测218例妊娠20~24周孕妇的血清BNP水平,并随访至分娩,其中25例发展为子痫前期(子痫前期组),另外193例正常妊娠者为对照组。结果:子痫前期组患者血清BNP水平为(104±7)pg/ml,对照组为(32±3.2)pg/ml,两组BNP水平比较差异有统计学意义(P<0.05);轻度子痫前期患者(8例)及重度子痫前期患者(17例)血清BNP水平分别为(49±4.5)pg/ml和(127±8.6)pg/ml,两组比较差异有统计学意义(P<0.05)。伴胎儿生长受限的子痫前期患者(10例)及妊娠32周前发病的子痫前期患者(5例)血清BNP水平分别为(123+7.8)pg/ml和(134+6.7)pg/ml,均明显高于未伴胎儿生长受限及妊娠32周后发病的子痫前期患者,差异有统计学意义(P<0.05)。以BNP水平48.6为界值,预测子痫前期的敏感度为73%,特异度为85%,阳性预测值为57%,阴性预测值为92%。结论:血清BNP水平可作为子痫前期的早期预测指标。
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关 键 词: | 子痫前期 脑利钠肽 妊娠 |
Predictive value of B-type natriuretic peptide in preeclampsia |
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Abstract: | Objective:To explore the predictive value of B-type natriuretic peptide (BNP) in preeclampsia.Methods:Serum BNP levels of 218 pregnant women at 20~24 gestation weeks were detected by immunofluorescence method,after follow-up until delivery,25 cases of preeclampsia were preeclampsia group and 193 cases of normal pregnancy were control group.Results:There was significant difference in BNP level between preeclampsia group (104±7.0) pg/ml] and control group (32±3.2) pg/ml] (P<0.05).There was significant difference in BNP level between mild preeclampsia group (8 cases) (49±4.5) pg/ml] and severe preeclampsia group (17 cases) (127±8.6) pg/ml] (P<0.05).The serum BNP levels in patients with fetal growth retardation (10 cases) and onset before 32 gestation weeks were (123±7.8) pg/ml and (134±6.7) pg/ml,which were significantly higher than those in patients without fetal growth retardation and onset after 32 gestation weeks (P<0.05).If serum BNP level was 48.6 pg/ml,the sensitivity,specificity,positive predictive value and negative predictive value were 73%,85%,57% and 92%,respectively.Conclusion:Serum BNP level can be used as an early predictive marker of preeclampsia. |
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Keywords: | Preeclampsia B-type natriuretic peptide Pregnancy |
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