妊娠女性体内铁含量对孕妇不宁腿综合征发病的影响

目的:探讨妊娠女性体内铁含量对孕妇不宁腿综合征发病的影响。方法:检测门诊孕期28周以上症状性不宁腿综合征孕妇、正常孕妇及健康女性体内血清铁、血清铁蛋白、血清可溶性转铁蛋白受体含量,并对检测结果做统计学分析。结果:血清铁、血清铁蛋白、血清可溶性转铁蛋白受体含量在症状性不宁腿综合征孕妇分别为(16.7±2.6)μmol/L、(29.3±3.2)μg/L和(38.2±8.5)nmol/L,在正常孕妇分别为(17.1±3.0)μmol/L、(30.2±4.4)μg/L和(36.0±6.3)nmol/L,在健康女性分别为(18.5±4.0)μmol/L、(36.8±5.9)μg/L和(27.9±4.3)nmol/L。症状性不宁腿综合征孕妇与健康女性在血清铁蛋白、血清可溶性转铁蛋白受体含量之间差异有统计学意义(P<0.01);不宁腿综合征孕妇与正常孕妇各检测指标之间差异无统计学意义。结论:妊娠女性体内铁缺乏可能是诱发孕妇发生不宁腿综合征的重要因素。

Effect of serum iron level on restless legs syndrome in pregnant women

Objective:To explore the effect of serum iron level on restless legs syndrome (RLS) in pregnant women.Methods:The serum levels of iron,ferritin and soluble transferrin receptor in pregnant women with RLS,normal pregnant women and healthy non-pregnant women were detected,and the results were analysed.Results:The serum levels of iron,ferritin and soluble transferrin receptor were (16.7±2.6) μmol/L,(29.3±3.2) μg/L,(38.2±8.5) nmol/L in pregnant women with RLS,(17.1±3.0) μmol/L,(30.2±4.4) μg/L,(36.0±6.3) nmol/L in normal pregnant women and (18.5±4.0) μmol/L,(36.8±5.9) μg/L,(27.9±4.3) nmol/L in healthy non-pregnant women.There was significant difference in serum levels of ferritin and soluble transferrin receptor between pregnant women with symptomatic RLS and healthy non-pregnant women (P<0.01);there was no significant difference in other indexes between pregnant women with RLS and normal pregnant women.Conclusion:Iron deficiency may be a major causative factor of RLS in pregnant women.