妊娠合并甲状腺功能减退症对孕妇及胎儿的影响

目的:探讨妊娠合并甲状腺功能减退症对妊娠结局及胎儿的影响。方法:回顾性分析40例妊娠合并甲状腺功能减退症的患者资料,采用放免法测定其血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)浓度及其对妊娠结局和胎儿的影响。结果:妊娠合并甲状腺功能减退症孕妇的流产率、早产率、并发症发生率及新生儿TSH升高明显高于对照组(P<0.05),新生儿出生后1minApgar评分低于正常对照组(P<0.05)。结论:对妊娠合并甲状腺功能减退症的孕妇应定期监测血清FT3、FT4、TSH浓度,及时调整用药剂量,并密切关注各类并发症的出现,以减少不良妊娠结局的发生;对其新生儿建议取脐带血监测血清FT3、FT4、TSH浓度,以及时发现新生儿甲状腺功能减退症,并及时治疗。

Effects of hypothyroidism during pregnancy on pregnant women and fetus

Objective:To explore the effects of hypothyroidism during pregnancy on pregnant women and fetus.Methods:Clinical data of 40 pregnant women with hypothyroidism were analysed retrospectively,then serum levels of thyroid-stimulating hormone (TSH),free triiodothyronine (FT3) and free thyroxine (FT4) were detected by radioimmunoassay.Results:The incidences of abortion,premature delivery and complications of pregnant women and TSH level of neonatal infants in hypothyroidism group were significantly higher than those in control group (P<0.05).The 1 minute Apgar score of neonatal infants in hypothyroidism group was significantly higher than that in control group (P<0.05).Conclusion:The serum levels of FT3,FT4 and TSH in pregnant women with hypothyroidism should be monitored throughout gestation,so as to find hypothyroidism of neonatal infants early and offer timely treatment.