| 131I-抗CD45单抗对淋巴造血组织选择性照射的研究 |
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| 引用本文： | 柴忆欢,吕慧,徐杰,范我,许玉杰,朱玲琍. 131I-抗CD45单抗对淋巴造血组织选择性照射的研究[J]. 中华核医学杂志, 2003, 23(4): 237-238 |
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| 作者姓名： | 柴忆欢 吕慧 徐杰 范我 许玉杰 朱玲琍 |
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| 作者单位： | 1. 215003,苏州大学附属儿童医院血液科
2. 苏州大学核医学院基础核医学教研室 |
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| 基金项目： | 江苏省卫生厅重点课题基金资助项目 (H2 0 0 1 0 5) |
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| 摘 要： | 目的 探讨^131I—抗CD45单克隆抗体(McAb)对小鼠淋巴造血组织选择性照射的效果。方法 由鼠尾静脉注入^131I—抗CD45 McAb和^125I—IgG，观察^131I—抗CD45 McAb在小鼠体内的分布情况。结果 ^131I—抗CD45 McAb较^125I-IgG从血液中清除更快。骨髓、脾脏可快速摄取^131I—抗CD45 McAb，其在骨髓、脾脏中有选择性积聚^125I-IgG呈非特异性分布。结论 ^131I—抗CD45 McAb在小鼠体内分布具有特异性，可对淋巴造血组织产生选择性照射。
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| 关 键 词： | ^131I—抗CD45单抗 淋巴造血组织 选择性照射 药代动力学 单克隆抗体 |
| 修稿时间： | 2002-12-18 |
Study of selective irradiation of lymphohematopoietic tissue delivered by 131 I-anti-CD45 McAb |
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| CHAI Yi-huan,LU Hui,XU Jie,et al.. Study of selective irradiation of lymphohematopoietic tissue delivered by 131 I-anti-CD45 McAb[J]. Chinese Journal of Nuclear Medicine, 2003, 23(4): 237-238 |
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| Authors: | CHAI Yi-huan LU Hui XU Jie et al. |
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| Affiliation: | CHAI Yi-huan,LU Hui,XU Jie,et al. Department of Hematology,Children's Hospital,Suzhou University,Suzhou 215003,China |
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| Abstract: | Objective To explore the lymphohematopoietic tissue targeting irradiation using 131I-anti-CD45 McAb. Methods 131I-anti-CD45 McAb or 125I-IgG was injected into the male mice via tail vein. The biodistribution of 131I-anti-CD45 McAb in mice was examined. Results 131I-anti-CD45 McAb was cleaned more quickly than 125I-IgG from the blood. The biodistribution studies showed persistent uptake of 131I-anti-CD45 McAb in bone marrow and the spleen. The injection of 125I-IgG resulted in an even distribution over the whole body. Conclusions 131I-anti-CD45 McAb showed a selective biodistribution in vivo. 131I-anti-CD45 McAb can target lymphohematopoietic tissues with relative specificity. |
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| Keywords: | Antibodies monoclonal Pharmacokinetics Hematopoietic system Radioimmunodetection Iodine radioisotopes Mice |
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