大剂量沐舒坦在上腹部手术围手术期中应用的临床研究

目的探讨大剂量沐舒坦在老年患者腹部手术术后的应用价值。方法将60例行腹部手术的老年患者随机分为大剂量沐舒坦组（观察组）和常规剂量沐舒坦组（对照组），每组30例。比较两组患者给药后血气分析、咳嗽、咳痰及肺部并发症情况。结果观察组与对照组术后第1天PaO2、PaCO2比较差异无统计学意义，第3、5天的PaO2、PaCO2比较，观察组高于对照组，差异有统计学意义（P〈0．05），两组患者术后咳嗽程度和咳痰难易程度，观察组优于对照组，差异有统计学意义（P〈0．05）；肺部并发症观察组少于对照组（P〈O．05），但肺不张两组比较则差异无统计学意义。结论老年患者腹部手术术后使用大剂量沐舒坦能降低肺部并发症．促进术后康复。

The clinical use of large dose Ambroxol in old patient undergoing abdominal operation

Objective To investigate the application value of high-dose Ambroxol in old patients after abdominal surgery. Methods 60 cases of the old patients after abdominal surgery were randomly divided into two groups. The observation group （n=30） with continuous intravenous infusion of high-dose Ambroxol; the control group （n=30） with continuous intravenous infusion of conventional doses Ambroxol. The level of PaO2, PaCO2, TCO2, expectoration, the incidence of pulmonary infection and the pulmonary atelectasis were analyzed. Results The level of PaO~,PaCO2,TCO= in the observation group were significantly superior to that of the control group （P〈0.05）. Large dose of Ambroxol by intravenous drip could cause the sputum in lung easy to become thin, cough up and be aspirated. The infection of lung infection in the treatment was significantly lower than that of＂ the control group, but the incidence of＂ the pulmonary atelectasis was the same of the two groups. Conclusion The large dose mucosolvan applied to the perioperative period of the upper abdominal operation are safe and effective, suggesting should popularized in the clinical application.