| Bcl-2基因家族在中枢神经系统中的作用 |
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| 引用本文： | 邵胜敏,王小同.Bcl-2基因家族在中枢神经系统中的作用[J].医学综述,2006,12(5):264-266. |
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| 作者姓名： | 邵胜敏 王小同 |
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| 作者单位： | 温州医学院附属第二医院,浙江,温州,325027 |
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| 摘 要： | Bcl-2家族在中枢神经系统发育和动态平衡中起重要的作用。在调节神经元分化方面Bcl-xl和Bax起决定性作用,而Bax和Bak在调节神经祖细胞量方面起作用。Bax、Bcl-xl和Bcl-2调节神经营养因子剥夺所引起的细胞凋亡。相反,细胞兴奋性中毒死亡不依赖于Bax或Bak,但Bak缺乏能增强神经兴奋因子的毒性。
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| 关 键 词： | 细胞凋亡 Bcl-2基因家族 基因剔除 中枢神经系统 神经元 |
| 文章编号： | 1006-2084（2006）05-0264-03 |
| 收稿时间： | 2005-08-21 |
| 修稿时间： | 2006-01-23 |
The Role of the Bcl-2 Gene Family in the Central Nervous System |
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| SHAO Sheng-min,WANG Xiao-tong.The Role of the Bcl-2 Gene Family in the Central Nervous System[J].Medical Recapitulate,2006,12(5):264-266. |
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| Authors: | SHAO Sheng-min WANG Xiao-tong |
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| Institution: | The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China |
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| Abstract: | The Bel-2 gene family plays important roles during the development and dynamic balance of Central Nervous System. Bcl-xl and Bax play crucial roles in regulating neuron differentiation. Bax and Bak play roles in regulating the amount of the neural progenitor cell. Bax, Bel-xl, and Bcl-2 regulate the apoptotic response caused by neurotrophic factor deprivation. In contrast, excitotoxie cell death does not dependend on either Bax or Bak. But the absence of Bax can enhance the toxicity of neuroexcitatory molecules. |
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| Keywords: | Apoptosis Bcl-2 genes Gene knocked out Central nervous system Neuron |
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