神经生长因子受体在腺样囊性癌神经侵袭中的作用

目的研究神经生长因子受体TrkA及p75在涎腺腺样囊性癌（ACC）嗜神经性中的作用。方法采用免疫组织化学方法（S-P法）检测40例涎腺腺样囊性癌组织中TrkA及p75的表达,并比较嗜神经组与非嗜神经组间Tr-kA/p75染色强度相对值的差异并进行统计分析。结果在40例ACC组织中,神经侵袭组19例,非神经侵袭组21例。TrkA表达阳性率90%,嗜神经组TrkA表达较非嗜神经组增强,差异有统计学意义（P〈0.05）。p75阳性表达率90%,嗜神经组p75表达较非嗜神经组亦增强,差异有统计学意义（P〈0.05）。嗜神经组TrkA/p75染色强度相对值较非嗜神经组显著增高,差异有显著统计学意义（P〈0.01）。结论 TrkA与p75的表达升高与ACC的嗜神经性均有关;TrkA在腺样囊性癌神经侵袭过程中可能发挥更为重要的作用。

Role of receptor of nerve growth factor on invasion of adenoid cystic carcinoma of human salivary glands

Objective To study the expression and the role of receptors of nerve growth factor in the perineural invasion of adenoid cystic carcinoma（ACC） of salivary glands.Methods The expression of TrkA and p75 were detected by immunohistochemistry in 40 cases adenoid cystic carcinoma tissues of different human salivary glands.Within the same sample we evaluate the expression of both TrkA and p75.Results In 40 cases of human adenoid cystic carcinoma,TrkA was positive in 36（90%） and p75 was positive in 36（90%）.TrkA and p75 were both positive in 33 cases.21 cases showed perineural invasion.The ratio of TrkA/p75 in perineural invasion team was higher than that of non-perineural invasion team（P0.01）.Conclusion TrkA may play an important role than p75 in the perineural invasion of adenoid cystic carcinoma of human salivary glands.