Biochemical, Hematological and Histological Changes in a Fulminant HeDatic Failure Rat Model for Ahificial Liver Assessment |
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| Authors: | Eduardo Chirito Colin Lister and Thomas M. S. Chang |
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| Affiliation: | Artificial Organs Research Unit, Mclntyre Medical Sciences Building, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada |
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| Abstract: | Galactosamine-induced fulminant hepatic failure rats have been used as a model for statistical assessment of liver support systems. The present study reports in detail the biochemical, hematological and histological changes in these animals. They have been used to study statistically the effects of ACAC charcoal hemoperfusion, cross-circulation and liver perfusion on long-term survival in fulminant hepatic failure. |
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| Keywords: | liver failure fulminant hepatic failure animal model artificial liver hemoperfusion charcoal liver support |
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