Autoradiographic localisation of opiate receptors in rat small intestine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Autoradiographic localisation of opiate receptors in rat small intestine

Authors:	M R Dashwood E S Debnam J Bagnall C S Thompson

Affiliation:	1. Department of Biological Sciences, University of Bergen, Bergen, Norway;2. Institute of Marine Research, Austevoll, Norway;3. Sogn Aqua AS, Bjordal, Norway;4. Institute of Marine Research, Tromsø, Norway;5. Institute of Marine Research, Bergen, Norway;1. Qinba Traditional Chinese Medicine Resources Research and Development Center, AnKang University, AnKang 725000, PR China;2. Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, 639, Longmian Road, Nanjing 211198, China;3. Department of Pharmacology of Traditional Chinese Medical Formulae, Nanjing University of Traditional Chinese Medicine, Nanjing, 138, Xianlin Road, Nanjing 210029, China;4. Department of Pharmacy, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

Abstract:	[3H]Naloxone and [3H]dihydromorphine are selective ligands for opiate receptors. Using an in vitro autoradiographic technique, binding of these ligands has been demonstrated to the villi and crypts in rat small intestine. These results indicate the presence of opiate receptor sites in the small intestine which suggests further a role for endogenous opiates in the transport functions of intestinal mucosa.

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