| 苦豆碱抗细菌感染作用机理的研究 |
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| 引用本文： | 黎雪如,周娅,王琦,薛筱芳. 苦豆碱抗细菌感染作用机理的研究[J]. 宁夏医科大学学报, 1991, 0(4) |
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| 作者姓名： | 黎雪如 周娅 王琦 薛筱芳 |
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| 作者单位： | 宁夏医学院微生物学教研室，宁夏医学院微生物学教研室，宁夏医学院微生物学教研室，宁夏医学院微生物学教研室 |
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| 摘 要： | 本文通过体内外实验研究了苦豆碱抗细菌感染作用的机理。体外抑菌试验证明苦豆碱具有杀死或抑制侵袭性大肠杆菌(EIEC)生长的作用。体内试验,通过腹腔注射活的 EIEC 给小鼠,结果证明苦豆碱能提高小鼠注射 EIEC 后48h内的生存率、能增强小鼠从脾脏清除细菌的能力、能增加抗菌抗体的效价和提高红细胞免疫功能。因此,作者认为苦豆碱抗细菌感染作用的机理,除苦豆碱的直接杀菌或抑菌作用外,还可通过提高机体的免疫功能来实现。
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| 关 键 词： | 苦豆碱 抗细菌感染 抑菌作用 免疫功能 |
The Mechanism of Aloperine on the Anti-bacterial Infactive Effect |
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| Li Xueru Zhou Ya Wang Qi Xue Xiaofang. The Mechanism of Aloperine on the Anti-bacterial Infactive Effect[J]. Journal of Ningxia Medical College, 1991, 0(4) |
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| Authors: | Li Xueru Zhou Ya Wang Qi Xue Xiaofang |
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| Abstract: | Aloperine's inhibition test against enteroinvasive Escherichia coli(EIEC) was proved to be positive in vitro.Through intraperitoneal inoculation of viable EIEC to mice,the mechanism of aloperine's anti-bacterial infective effect was investigated in vivo.The results showed that aloperine enhanced mice's survival rate (within 48h)following the attack of EIEC infection, increased the bacteria-removal ability from mouse spleen,raised titers of anti-bacteuial antibodies and enhanced the immunologic function of mouse erythrocytes.The authors consider that the anti-bacterial infective effect of aloperine is due to an enhancement of immunocompetence besides a direct inhibitory or bactericidal effects in the experimental mice. |
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| Keywords: | aloperine anti-bacterial infection bacteriostasis immunocompetence |
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