HLA-DR表达与卵巢癌临床病理及预后的关系

目的:探讨HLA-DR与卵巢癌临床病理参数及预后的关系。方法:应用免疫组化SP方法检测卵巢癌、卵巢良性上皮肿瘤及正常卵巢组织中HLA-DR的表达。结果:卵巢癌组织中HLA-DR阳性率为57.89%(33/57),显著高于正常卵巢组织及良性上皮肿瘤(P<0.05),早期卵巢癌HLA-DR的阳性率显著高于晚期(P<0.01);高分化组HLA-DR的阳性率显著高于中、低分化组(P<0.05);HLA-DR阳性率与肿瘤组织局部淋巴细胞浸润程度呈正相关(P<0.05)。结论:①HLA-DR异常表达可能与卵巢癌的发病机制有关;②HLA-DR的低表达预示卵巢癌恶性程度高。

THE RELATIONSHIP BETWEEN HLA-DR EXPRESSION AND CLINICOPATHOLOGY AND PROBNOSIS OF OVARIEN EPITHELIAL CARCINOMA

Objective: To investigate the relationship between HLA-DR antigen expressionof ovarian epithelial carcinoma (OEC) and the clinicopathology and prognosis of OEC. Methods: Streptomyces avidin-Peroxidase (S-P) immunohistochemical method was used to detect the HLA-DR antigen expressions in normal ovarian tissues, ovarian epithelial benign tumor and ovarian epithelial carcinomas respectively. Results: The positive rate of HLA-DR was 57.89 %(33/57) in OEC,which was obviously higher than that in both benign epithelial ovarian tumor and normal ovarian tissues (P<0.05). Significant difference was found in the positive rate of HLA-DR between early and late stages (P<0.01). The positive rate of HLA-DR was obviously higher in high differentiated group than that in median and low differentiated groups (P<0.05). The positive rate of HLA-DR was positively correlated with lymphocyte infiltration of local tumor tissue (P<0.05). Conclusions: ①The abnormal expression of HLA-DR may be associated with the pathogenesis of ovarian carcinoma. ②Lower HLA-DR expressionmay predict higher malignancy of ovarian carcinoma.