| 矽肺大鼠肺中硅/铝比值的动态变化及其在矽肺发病中的意义 |
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| 引用本文： | 张宝旭,刘世杰.矽肺大鼠肺中硅/铝比值的动态变化及其在矽肺发病中的意义[J].北京大学学报(医学版),1989(3). |
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| 作者姓名： | 张宝旭 刘世杰 |
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| 作者单位： | 北京医科大学劳动卫生教研室
(张宝旭)，北京医科大学劳动卫生教研室(刘世杰) |
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| 摘 要： | 本研究分析了矽肺大鼠肺中石英和铝的相互关系,发现矽肺大鼠肺矽结节中石英和铝存在正相关关系(r=0.5,P<0.05),提示石英有吸引铝并与之结合的能力。当矽肺大鼠给予柠檬酸铝后肺中硅/铝比值发生变化,并与肺部病变成正相关。提示硅/铝比值的大小可以反映石英粉尘的致纤维化能力。为进一步证实预防性给铝可增强抗矽尘致病能力提供了新的依据。
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| 关 键 词： | 矽肺 铝 石英 硅/铝比值 |
VALUE OF Si/Al RATIO IN THE DEVELOPMENT OF RAT SILICOSIS |
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| Institution: | Department of Occupational Health Zhang Baoxu,Liu Shijie |
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| Abstract: | Quartz and Aluminium (Al) were determined in lungs of silicotic rats. There was positive correlation between quartz and Al content in the silicotic nodules (r = 0.5r p<0.05). After Al citrate treatment, the Si/Al ratio decreased in the lungs and hilar lymph nodes. A positive correlation between Si/Al ratio and dry lung weight was found (r=0.5, p<0.01). Si/Al ratio can reflet the degree of fibrogenicity of silica dust. The result supports that Al pre-treatment can help prevent silicosis. |
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| Keywords: | Silicosis Aluminium Quartz Si/Al ratio |
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