细胞衰老在老年骨质疏松症防治中的研究进展

越来越多的研究认为衰老是许多年龄相关疾病的最大危险因素,认为抑制衰老可延迟多种慢性病的出现或降低其严重程度,老年骨质疏松症常与这些衰老相关疾病共存。临床前研究和动物实验发现,随着衰老,骨微环境中的衰老细胞增加,衰老相关的促炎性分泌蛋白产生增多,导致骨吸收增加和骨形成减少。而消除衰老细胞或抑制促炎性分泌蛋白的产生可预防年龄相关的骨丢失。本文就细胞衰老对老年骨质疏松症的影响作分析总结,综述近年来研究进展,以期为老年骨质疏松症的研究与治疗提供参考。

Progress on research of cellular senescence in the prevention and treatment of age-related osteoporosis

A number of studies suggest that aging is the greatest risk factor for many age-related diseases. It is believed that inhibition of aging can delay the appearence or reduce the severity of many chronic diseases. Osteoporosis is often associated with these aging-related diseases. Preclinical studies and animal experiments have found that with aging, senescent cells in the bone microenvironment increase,which can produce senescence-associated secretory phenotype, resulting in increased bone resorption and decreased bone formation. Elimination of senescent cells or inhibition of the production of pro-inflammatory secretory proteins prevents age-related bone loss. In this paper, we analyzethe effects of cell senescence on age-related osteoporosisand summarizethe research progress in recent years, aiming to provide reference for the research and treatment of age-related osteoporosis.