| 基于脑源性神经营养因子探讨针刺治疗认知障碍的机制及思路＊ |
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| 引用本文： | 李思妤,胡琼,郎娟,汪海燕,张虹. 基于脑源性神经营养因子探讨针刺治疗认知障碍的机制及思路＊[J]. 世界科学技术-中医药现代化, 2020, 22(6): 2006-2012 |
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| 作者姓名： | 李思妤 胡琼 郎娟 汪海燕 张虹 |
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| 作者单位： | 成都中医药大学针灸推拿学院 成都610075 |
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| 基金项目： | 国家自然科学基金面上项目(81873384)：基于BDNF-TrkB通路探讨疏肝调肾针法对PTSD大鼠海马、杏仁核突触可塑性损伤修复的机制研究;负责人：张虹。其中立项部门：国家自然科学基金委员会;项目类型：面上项目;编号：81873384;名称：基于BDNF-TrkB通路探讨疏肝调肾针法对PTSD大鼠海马、杏仁核突触可塑性损伤修复的机制研究;负责人：张虹;四川省科技计划项目重点研发项目（2018SZ0072）：基于数字化平台探讨“三才益智灸”结合“同时多重任务”干预MCI以预防老年痴呆的社区优势方案及机制研究;负责人：张虹;其中立项部门：四川省科学技术厅;项目类型：重点研发项目;编号：2018SZ0072;名称：基于数字化平台探讨“三才益智灸”结合“同时多重任务”干预MCI以预防老年痴呆的社区优势方案及机制研究;负责人：张虹。 |
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| 摘 要： | 阿尔茨海默病是严重的神经退行性疾病,认知障碍是其核心症状。近年来的研究发现,脑源性神经营养因子介导的信号通路及其相关受体在神经传导中有选择性的激活与表达,进而改善认知功能。本研究基于脑源性神经营养因子研究针刺治疗认知障碍的作用机理,以期为针刺治疗认知障碍的机制提供新的思路。
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| 关 键 词： | 脑源性神经营养因子 针刺 认知障碍 综述 |
| 收稿时间： | 2019-06-30 |
| 修稿时间： | 2020-06-01 |
Acupuncture for Cognitive Impairment Based on Brain Derived Neurotrophic Factor: Mechanisms and Perspectives |
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| Li Siyu,Hu Qiong,Lang Juan,Wang Haiyan and Zhang Hong. Acupuncture for Cognitive Impairment Based on Brain Derived Neurotrophic Factor: Mechanisms and Perspectives[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2020, 22(6): 2006-2012 |
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| Authors: | Li Siyu Hu Qiong Lang Juan Wang Haiyan Zhang Hong |
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| Affiliation: | College of Acupuncture and Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, China,College of Acupuncture and Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, China,College of Acupuncture and Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, China,College of Acupuncture and Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, China,College of Acupuncture and Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, China |
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| Abstract: | Alzheimer s disease is a serious neurodegenerative disease with cognitive impairment as its core symptom. Recent studies have found that brain derived neurotrophic factor-mediated signaling pathways and their associated receptors are selectively activated and expressed in nerve conduction, thereby improving cognitive function. Based on brain derived neurotrophic factors, this paper studies the mechanism of acupuncture in the treatment of cognitive impairment, so as to provide new ideas for the mechanism of acupuncture in the treatment of cognitive impairment. |
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| Keywords: | Brain derived neurotrophic factor acupuncture cognitive impairment review |
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