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Clinical characteristics and laboratory analysis of Epstein-Barr Virus infection and infectious mononucleosis in children.

??Objective To investigate clinical characteristics and laboratory feature of Epstein-Barr Virus??EBV?? infection and infectous mononucleosis in children. Method A retrospective study was conducted in 108 hospitalized patients who were enrolled from Jan 2010 to May 2011.Among them 77 patients were diagnosed with IM. Results In our investigation most of the IM was seen in preschool children??41.6%??and in young children??36.4%?? . Eyelid edema was common clinical manifestations of IM??the percentage of which was higher than enlarged spleen and rash in IM group.Increased ratio of atypical lymphocytes ??≥10%?? was seen in only 33.8% of the IM patients.The EBV-DNA level in plasm of IM patients was in the range of 1.04 × 103??2.88 × 105 copies/mL??with a mean value of 7.18 × 104 copies/mL. All of 3 cases of EBV-HLH in our study were negative in sera of anti-VCA-IgM?? but were positive of EBV-DNA in plasma and mean EBV-DNA loads were 2.71 × 107 copies/mL. Conclusion In our observation eyelid edema has the same diagnostic value as the other typical manifections in IM.The clinical significance of atypical lymphocyte in the diagnosis of IM??especially in infants and young children??needs to be further confirmed.EBV-DNA copy in peripheral blood seems to be closely related to the active infection of EBV and in EBV-HLH the diagnostic value of detection of EBV-DNA in serum by FQ-PCR should be emphasized.