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Effectiveness of ALL-2005 protocol in the treatment of acute lymphoblastic leukemia in infants.

??Abstract??Objective To evaluate the therapeutic effectiveness and prognostic factors of ALL in infants treated with ALL-2005 protoco1. Methods Eighty-eight patients with ALL under 3 years of age were retrospectively studied ??who were newly diagnosed by morphologic and immunologic genetics and molecular biology ??MICM???? and were enrolled in the ALL-2005 treatment protocol from May 2005 to April 2009 in Shanghai Children’s Medical Center SCMC. Results Data were retrospectively collected since 2005 using the pediatric oncology networked database ??POND??. And altogether 88 children under 3 years of age with ALL received treatment in SCMC in the following four years. Among the 88 cases of ALL?? 61 ??69.32%?? were males and 27 ??30.68%?? were females. The median age at diagnosis was 2.08 years ??0??2.92 years??. Eighy-four were B lineage-ALL and 4 were T lineage-ALL. Thirty-six ??40.91%?? children were classified as low-risk?? 50 ??56.82%?? were standard-risk and 2 ??2.27%?? were high-risk. Eighty-one??92.05%?? children completely remitted in induction while 17 ??19.32%?? children relapsed. After a median follow-up of 33 months ??1.0??68.2 months???? the estimated 5-year event free survival ??EFS??rate and overall survival rate were 69.51% and 82.95%?? respectively. Conclusion The estimated 4-year EFS of ALL in infants has been close to 70%?? the therapeutic effectiveness of the ALL-2005 protocol for ALL in infants is satisfactory.