急性冠脉综合征患者血浆sOX40L、sP选择素的变化水平及与冠脉病变的相关性研究

目的探讨可溶性OX40L(sOX40L)在不同类型冠心病(CHD)患者血浆中的变化水平,及其与可溶性P选择素(sP选择素)、C反应蛋白(CRP)、冠脉病变程度的关系。方法采用ELISA法测定血浆中sOX40L、sP选择素的水平,免疫散射比浊法测定CRP,同时测定空腹血糖、血脂等指标。按照Califf危险分数来评价冠状动脉造影(CAG)结果所显示的冠脉病变情况。结果急性冠脉综合征(ACS)组血浆sOX40L、sP选择素、CRP水平较稳定性心绞痛(SAP)组及对照组明显为高(P<0.05);相关分析显示,sOX40L与sP选择素、CRP呈显著正相关;与冠脉危险分数、血脂等未显示相关性。结论ACS患者血浆中sOX40L、sP选择素、CRP水平明显升高,提示可能与ACS的发生有关。炎症在不稳定斑块的破裂中起到重要作用,其中OX40/OX40L共刺激信号通路可能是一个中心机制。sOX40L可发展为新的标志物来早期预测易损斑块。

STUDY OF PLASMA SOX40L AND SP-SELECTIN LEVELS AND THEIR CORRELATIONS TO THE SEVERITY OF CORONARY LESION IN ACUTE CORONARY SYNDROME

Objective To explore the difference of plasma soluble OX40 ligend(sOX40L) in different subtype of coronary heart disease(CHD) and it's relationship with soluble P-selectin(sP-selectin),C-reactive protein(CRP)and the variety of coronary artery injury.Methods Enzyme-linked immunoabsorbent assay(ELISA) was used to measure the plasma sOX40L,sP-selectin,CRP,Serum glucose and lipids at the same time.All patients with coronary angiography(CAG) and coronary artery injury were evaluated.Results The levels of sOX40L,sP-selectin and CRP were significantly higher in patients with acute coronary syndrome(ACS) than in those of control group and stable angina pectoris(SAP) group(P<0.05).Correlation analysis suggested their levels were positively correlated with each other.But they had no significant correlation with coronary artery injury and serum lipids.Conclusion The elevated levels of sOX40L,sP-selectin and CRP in ACS suggested that they may be correlated with the pathogenesis of ACS.Inflammation may play an important role in the rupture of plaque instability,in which OX40/OX40L co-stimulatory signal pathway may be a center mechanism.sOX40L can be served as a potential new marker to predicting the vulnerable plaque in earlier.