| 绿脓杆菌内毒素蛋白疫苗治疗绿脓杆菌感染207例 |
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| 引用本文： | 敬德仲,卢东升,李文贤,田福泉,刘秉锟,李国佳,刘新贺,张德桂,邵明祥. 绿脓杆菌内毒素蛋白疫苗治疗绿脓杆菌感染207例[J]. 中国新药与临床杂志, 1989, 0(6) |
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| 作者姓名： | 敬德仲 卢东升 李文贤 田福泉 刘秉锟 李国佳 刘新贺 张德桂 邵明祥 |
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| 作者单位： | 黑龙江省科学院应用微生物研究所，黑龙江省科学院应用微生物研究所，黑龙江省科学院应用微生物研究所，黑龙江省人民医院、，北京医学院附属第一医院、，北京医学院附属第三医院，北京第二医学院附属宣武医院，哈尔滨市第三医院、，哈尔滨铁路局中心医院 哈尔滨 150010，哈尔滨 150010，哈尔滨 150010 |
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| 摘 要： | 本文报告绿脓杆菌内毒素蛋白疫苗对207例绿脓杆菌感染的临床疗效。121例烧伤后绿脓杆菌感染患者中31例治疗后创面细菌培养29例阴转(94％),治疗组阴转率明显高于对照组(P<0.05),创面愈合时间明显缩短。86例非烧伤绿脓杆菌感染患者治疗后总有效率为79％,伤口术后感染疗效高达92％。
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| 关 键 词： | 假单胞菌感染 内毒素 疫苗 |
Treatment of 207 patients of Pseudomonas aeruginosa infections with its endotoxin-protein vaccines |
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| JING De-Zhong,LU Dong-Sheng,Ll Wen-Xian,TIAN Fu-Quan,LIU Bing-Kun,LI Guo-Jia,LIU Xin-He,ZHANG De-Gui,SHAO Ming-Xiang. Treatment of 207 patients of Pseudomonas aeruginosa infections with its endotoxin-protein vaccines[J]. Chinese Journal of New Drugs and Clinical Remedies, 1989, 0(6) |
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| Authors: | JING De-Zhong LU Dong-Sheng Ll Wen-Xian TIAN Fu-Quan LIU Bing-Kun LI Guo-Jia LIU Xin-He ZHANG De-Gui SHAO Ming-Xiang |
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| Abstract: | 207 patients of Pseudomonas aeruginosa infections were treated with corresponding vaccine prepared from endotoxin-protein of this micro-organism (EP). As a preventive measure in 121 burn patients, EP definitely reduced the chance of infection as compared with the controls (P<0.05). Among them 31 patients had their wound-surface-culture positive to this micro-organism. EP not only promoted the wound-healing but also cleared this micro-organism away from the wound in 29 out of 31 cases (94%). In 86 non-burn patients due to Pseudomonas aeruginosa infections in general, EP was also very effective therapeutically. For the post-operative cases, EP could reduce the chance of infection due to this micro-organism from 92 to 67%. |
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| Keywords: | Pseudomonas infections endotoxins vaccines |
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