雌激素的抗抑郁作用及机制研究进展

摘要 抑郁症困扰着世界上大概三亿四千万人。已成为致死亡和劳动能力丧失的重大疾病之一。女性患病率约为男性的两倍，提示雌激素可能参与发病机制。多项研究表明，女性抑郁症患者雌激素水平降低，治疗后雌激素水平增高。但对男性研究较少。雌激素对抑郁症的治疗作用在一些研究中得到肯定，但其机制需进一步阐明。雌激素的副作用成为临床应用及研究的制约因素。进一步的研究将对抑郁症的诊断及治疗有重要意义。

Research Progress of The Antidepression Effects of Estrogen And The Mechanism

Abstract Depression affects 340 million people around the world. It has become one of the major cause of death and disability. Depression occurs in women about twice as in men ,which suggest that estrogen may play a role .Many researches have shown that E2 in plasma is significantly lower in women with depression than those with no depression and increased after treatment .But there is few research on men about that. Efficacy of estrogen for the treatment of depression is positive in some research. But the mechanism is to be further probed. The side effect of estrogen has restricted its clinical use. Further research might gain more meaningful result.