Neuroendocrine Differentiation in a Case of Acinic Cell Carcinoma of the Parotid Gland |
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| Authors: | Kunihisa Ito Kennichi Kakudo Ichiro Mori Masatoshi Horiuchi Yoshiyuki Osamura |
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| Affiliation: | Department of Pathology, Tokai University, School of Medicine, Isehara.;Department of Oto rhino laryngology, Tokai University, School of Medicine, Isehara. |
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| Abstract: | We report a case of acinic cell carcinoma of the parotid gland with neuroendocrine differentiation. Light microscopically, the tumor appeared as clear cell-type acinic cell carcinoma. In addition, the tumor showed neurosecretory features such as Grimelius positivity and the presence of neurosecretory granules by electron microscopy. We suggest that a tumor cell arising from a stem cell can show simultaneous differentiation to both neuroendocrine and acinic cells. |
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| Keywords: | Parotid gland Acinic cell tumor Neuroendocrine cell |
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