Tissue distribution of histamine in a mutant mouse deficient in mast cells: Clear evidence for the presence of non-mast-cell histamine |
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Authors: | Yamatodani Atsushi Maeyama Kazutaka Watanabe Takehiko Wada Hiroshi Kitamura Yukihiko |
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Institution: | 1. Department of Pharmacology II, Osaka University School of Medicine, Osaka, Japan;2. Institute for Cancer Research, Osaka University School of Medicine, Osaka, Japan |
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Abstract: | The contents of histamine in various tissues of mutant mice deficient in mast cells () and in congenic normal mice (+/+) were determined by high-performance liquid chromatography and were compared. In spite of the absence of mast cells in mice, the histamine content of their whole bodies was about 5–10% of that of +/+ mice. The skin, heart and lungs of mice contained negligible amounts of histamine (about 2% of that in +/+ mice), but the liver, kidneys and spleen contained appreciable histamine (8–15% of that in +/+ mice), and the brain and stomach contained much histamine (45 and 34%, respectively, of that in +/+ mice). These results indicate the presence of non-mast-cell histamine, especially in the brain and stomach, where it may play important physiological roles. |
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Keywords: | Address all correspondence to: Dr Atsushi Yamatodani Department of Pharmacology II Osaka University School of Medicine 3–57 Nakanoshima 4 Kitaku Osaka 530 Japan |
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