Sulfation of minoxidil by liver sulfotransferase |
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Authors: | Garland A Johnson Karen J Barsuhn John M McCall |
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Institution: | Cardiovascular Diseases Research, The Upjohn Co., Kalamazoo, MI 49001, U.S.A. |
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Abstract: | The 100,000 g supernatant fraction of rat liver homogenate contains a sulfotransferase activity which catalyzes the sulfation of minoxidil. Synthetic minoxidil N-O sulfate and the enzyme synthesized product had identical Chromatographie characteristics on high pressure liquid chromatography. Minoxidil sulfate, which yields minoxidil when treated with sulfatase, was slowly hydrolyzed in water. Several N-oxides of other heterocycles, including several other pyrimidines, triazines and imidazoles, were also substrates for this sulfotransferase. |
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Keywords: | Send correspondence to: Garland A Johnson Cardiovascular Diseases Research The Upjohn Co Kalamazoo MI 49001 U S A |
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