| 卡托普利对阿霉素心脏毒性作用的影响 |
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| 引用本文： | 皮修军,陈修. 卡托普利对阿霉素心脏毒性作用的影响[J]. 中南大学学报(医学版), 1994, 0(2) |
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| 作者姓名： | 皮修军 陈修 |
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| 作者单位： | Pi Xiujun Department of Physiology，Hunan Medical University Chen Xiu Department of Pharmacology，Hunan Medical University |
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| 摘 要： | 用离体大鼠心脏灌流模型观察了卡托普利（ｃａｐｔｏｐｒｉｌ，ＣＡＰ）对阿霉素（ａｄｒｉａｍｙｃｉｎ，ＡＤＭ）急性心肌毒性作用的影响。结果表明，ＡＤＭ（６ｍｇ／Ｌ）灌注能造成心肌收缩力的严重损害，冠脉灌注压的明显升高和心肌丙二醛含量的增加；治疗剂量的ＣＡＰ（４０ｍｇ／Ｌ）并不能保护心肌，反而加重了ＡＤＭ对心脏的毒性作用。作者认为，在防治ＡＤＭ所致的心功能不全时应慎用ＣＡＰ。
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| 关 键 词： | 阿霉素；卡托普利；副作用；心肌；毒性；丙二醛；疾病模型，动物；大鼠 |
EFFECTS OF CAPTOPRIL ON ACUTE ADRIAMYCIN CAKDIOTOXICITY |
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| Pi Xiujun. EFFECTS OF CAPTOPRIL ON ACUTE ADRIAMYCIN CAKDIOTOXICITY[J]. Journal of Central South University. Medical sciences, 1994, 0(2) |
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| Authors: | Pi Xiujun |
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| Affiliation: | Pi Xiujun Department of Physiology,Hunan Medical University Chen Xiu Department of Pharmacology,Hunan Medical University |
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| Abstract: | |
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| Keywords: | adriamycin captdpril adverse effects myocardium toxicity malondialdehyde disease models animal:rats |
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