CD90在胃癌中的表达及其临床意义

目的:探讨CD90在胃癌组织中的表达及其临床意义?方法:通过免疫组织化学双染法检测CD90在胃癌组织?癌旁组织和慢性胃炎组织中的表达,以研究其与胃癌临床病理因素及预后的关系?结果:CD90表达阳性率在胃癌组织中为66.7%(64/96),在癌旁正常组织中为15.6%(15/96),在慢性胃炎组织中为15.0%(3/20),差异有统计学意义(P < 0.01);CD90在胃癌中的表达与TNM分期有关(P=0.014,PT=0.02,PN=0.017,PM=0.045;另外在多因素生存分析中,CD90高表达的患者均有更差的5年总生存率(P < 0.05)?结论:CD90可能与胃癌的侵袭与转移相关,有可能为治疗提供一个新的分子靶点,并判断胃癌患者的预后?

Expression and clinical significance of CD90 in gastric cancer

Objective:To investigate the expression of CD90 and its clinical significance in gastric cancer tissues. Methods: The expressions of CD90 in gastric cancer tissues, adjacent tissues and chronic gastritis tissues were detected by immunohistochemical staining to analyze their relationship with clinical pathological features and prognosis in gastric cancer. Result: The positive expression rate of CD90 was 66.7%(64/96)in gastric cancer tissues, 15.6%(15/96)in adjacent normal tissues, and 15.0% (3/20) in chronic gastritis tissues, with a statistically significant difference (P < 0.01). The expression of CD90 in gastric cancer was associated with the TNM stage (P=0.014, P T=0.02,PN=0.017 and PM =0.045). Multivariate survival analysis indicated that patients with high expression of CD90 had poorer 5-year overall survival (P < 0.05). Conclusion: CD90 is associated with the invasion and metastasis of gastric cancer, and may be helpful in providing a novel molecular therapeutictarget and evaluating prognosis of gastric cancer.