Cyclic change of cytokines in a patient with cyclic thrombocytopenia |
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Authors: | Fumihiko Kimura Yukistugu Nakamura Ken Sato Naoki Wakimoto Takashi Kato Tomoyuki Tahara Muneo Yamada Naokazu Nagata & Kazuo Motoyoshi |
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Institution: | The Third Department of Internal Medicine, National Defence Medical College, Saitama,;Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd, Gunma, and;;Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd, Kanagawa, Japan |
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Abstract: | The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described. Interleukin 7, stem cell factor, and transforming growth factor β1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role. |
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Keywords: | cyclic thrombocytopenia interleukin-7 thrombopoietin M-CSF stem cell factor |
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